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Pre–steady-state kinetic parameters for acylation and deacylation rates for imipenem hydrolysis
| KPC mutants | k2 (s−1) | k3 (s−1) |
|---|---|---|
| Wildtypea | 210 ± 70 | 60 ± 20 |
| F72Y | 74 ± 7 | 0.2 ± 0.05 |
| T215P | 180 ± 30 | 0.4 ± 0.20 |
k2 and k3 values from Mehta et al., 2020.
