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. 2021 Jun 9;7(24):eabg6005. doi: 10.1126/sciadv.abg6005

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3 — (A) Single-cell transcriptomic sequencing of wild-type (WT) mouse lung total single cells. Ghr gene expression is mainly in Col1a1⁺ cell cluster. (B) CAMC (mesenchymal cells defined by Col1a1 and Acta2) were reclustered and plotted for Ghr and Col1a1 coexpression. Around 88.35% of the total Ghr⁺ cells are Col1a1⁺. (C) Ghr expression in ATII cells by single-cell RNA-seq analysis. About 6.59% Sftpc⁺ ATII cells are Ghr⁺. (D) ATII expression of Ghr and Sftpc. (E) Top up-regulated genes for Ghr-positive mesenchymal cells compared with Ghr-negative mesenchymal cells. (F) Fluorescence-activated cell sorting (FACS) analysis of Ghr on cell surface of cultured passage 3 primary lung mesenchymal cells (Epcam⁺Cd31/45⁺ cells were excluded) from normal and bleomycin-treated mice (7, 14, and 21 days after bleomycin administration).