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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Mol Carcinog. 2021 Mar 8;60(5):331–341. doi: 10.1002/mc.23295

Figure 6: Schematic of NRF2 induction via FAM129B in mutant BRAF cells.

Figure 6:

Constitutive activation of the MAPK signaling pathway via a mutation in BRAF (V600E) increases phosphorylation of FAM129B and mediates its cytosolic localization. In turn, FAM129B binds to KEAP1, preventing association between KEAP1 and NRF2, thus NRF2 protein accumulates, translocates to the nucleus, and activates transcription of its target genes.