FIG 2.

Noninferiority analysis of proportion of responders for the intention-to-treat (ITT) population in all women and stratified by menopausal status. In the ITT population (N = 1,230), the figure shows the proportions of women who had a larger decrease than median relative density decrease in the 20 mg arm (–10.1%) for all women at study exit, stratified by menopausal status and tamoxifen dose. The proportions of women in the 20 mg arms who had a larger decrease than median decrease are denoted with short-dashed lines, and the noninferiority margins of 33% are denoted with long-dashed lines. The Holm P values show Bonferroni-Holm–corrected one-sided tests with rejected null hypotheses for noninferiority of all women.