Figure 3.

Early adolescent male mice demonstrate cocaine CPP that is stable ten days after the initial test. A. Experimental timeline of cocaine or social CPP. B/D. Cocaine CPP measured as the duration spent in the drug-paired chamber during test; retest was conducted ten days later (P56 at pretest). Time spent in the saline-paired chamber is shown in D. C/E. Using a procedure identical to the cocaine CPP procedure and substituting social interaction for drug reward does not change the time spent in the social-paired chamber (C) or the time spent in the isolation-paired chamber (E). produce place preference (P56 at pretest).