Fig. 5.

Literature-derived mechanisms between ‘Sleep duration’, ‘Leptin’ and ‘Coronary Heart Disease’. Network diagram displaying the literature connections between ‘Sleep Duration’ and ‘Coronary Heart Disease’ through the intermediate term ‘Leptin’. Predicates connecting two semantic terms, their frequencies and enrichment P-value are labelled on the edges. Enrichment is calculated via MELODI Presto (Elsworth and Gaunt, 2020) based on a comparison of query count to background. Edge width represents the enrichment log transformed P-value. Red nodes represent the exposure (SLEEP DURATION) and outcome (CORONARY HEART DISEASE) traits, blue nodes represent intermediate semantic literature nodes