Table 3.

Summary of disease traits identified with causal association to ‘Sleep duration’

Exposure	Outcome	MR beta	MR P-value	Disease
ieu-a-1088: sleep duration	ukb-a-107: non-cancer illness code self-reported: gout	−0.00257	3.8 $\times$ 10−24	‘gout’
ieu-a-1088: sleep duration	ieu-a-6: coronary heart disease	−1.03933	2.3 $\times$ 10−21	‘coronary artery disease’
ieu-a-1088: sleep duration	ukb-a-548: Diagnoses - main ICD10: K35 acute appendicitis	−0.00671	8.0 $\times$ 10−15	‘appendicitis’
ieu-a-1088: sleep duration	ukb-a-54: cancer code self-reported: lung cancer	−0.00191	1.1 $\times$ 10−14	‘cancer’, ‘lung carcinoma’
ukb-a-9: sleep duration	ukb-a-13: sleeplessness/insomnia	−0.32167	1.1 $\times$ 10−11	‘insomnia (disease)’

Note: We searched for MR evidence associated with the trait ‘Sleep duration’ with P-value to be under 1 $\times$ 10⁻¹⁰, and map the outcome trait to a disease term via mappings through EFO terms. The identifiers ‘ieu-a-’/‘ukb-a-’ are IEU OpenGWAS IDs.