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. 2021 Jun 9;41(7):1502–1506. doi: 10.1007/s10875-021-01081-9

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© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 1 — SARS-CoV-2 infection and impact of STAT1 pathway in the presence of ruxolitinib. Evaluation of the JAK/STAT1 pathway by flow cytometry (A, B) and qPCR (C). Non-stimulated STAT1 levels in CD8⁺ T cells before and during SARS-CoV-2 infection (A); pSTAT1 levels in CD8 + T cells pre- and post-stimulation with IFNα before and during SARS-CoV-2 infection (B). Expression of STAT1, CXCL10, and PD-L1 (from left to right) in PBMCs pre- and post-stimulation with IFNα before and during SARS-CoV-2 infection (C). Data from non-stimulated and stimulated samples represented as white and black symbols, respectively. Control and patient data represented as circles and squares, respectively. The presented data in A and B has been normalized to non-stimulated samples from healthy controls. PBMCs, peripheral blood mononuclear cells; NS, non-stimulated; IFNα, stimulated with IFNα; gMFI, geometric mean fluorescence intensity. Molecular/serological SARS-CoV-2 results during infection (D). CT, cycle threshold; ORF1ab, Open Reading Frame ab gene. ELISA determinations of IL-6, IFNγ, and CXCL10 serum levels during infection (E)