Figure 4.

Heatmap of standardized gene expression

The colors represent standardized expression values centered around 0, with variance equal to 1. Each column represents a subject. This heatmap was built by unsupervised hierarchical clustering of log2-counts-per-million RNA-seq transcriptomic data from whole blood (29,302 genes) and subjects (n = 54) using the Euclidean distance and Ward's method. Seven blocks are highlighted as per the features of gene expression across the groups of individuals. Enrichment (number and % of genes of a given pathway selected in the block) of pathways of interest are shown for each block.

See also Table S1.