Figure 6.

Distribution of the CD177 marker and association with clinical outcomes of patients with COVID-19

(A) Measurement of CD177 (ng/mL). HD: Healthy donors (n = 16), patients with COVID-19 (n = 203). The difference between the two groups was evaluated using Wilcoxon rank sum statistical tests. The median values (horizontal line in the boxplot) are shown. The lower and upper boundaries of the box represent the 25% and 75% percentiles.

(B) Correlation between normalized CD177 values of gene expression measured by RNA-seq and CD177 protein by ELISA (ng/mL) from 36 patients with COVID-19. The blue line represents the linear regression line and the gray area the 95% prediction confidence interval.

(C) Association between CD177 serum concentration and time from symptom onset to the admission (n = 192). This association was tested using Spearman correlation tests. The blue line represents the linear regression line and the gray area the 95% confidence interval.

(D) Measurement of CD177 serum concentration in patients hospitalized in an intensive care unit (ICU) or not (n = 196). Wilcoxon rank tests were used. The median values (horizontal line in the boxplot) are shown. The lower and upper boundaries of the box represent the 25% and 75% percentiles.

(E) Change of CD177 concentration over time according to the occurrence of death for 172 patients with COVID-19 and a total of 248 measurements. Predictions were calculated using a mixed effect models for longitudinal data.

See also Figure S6.