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(a) Diagram of the domains in the SARS-CoV-2 nsp12 with motifs A–G. Tertiary structures of (b) SARS-CoV-2 RdRp and (c) SARS-CoV RdRp determined by using cryo-EM. NiRAN domain, interface domain, fingers domain, palm domain, and thumb domain are drawn by purple, green, orange, blue, and red, respectively, corresponding to the colors shown in Fig. 1a. The nsp7 and two nsp8s (nsp8-1 and nsp8-2) cofactors are also drawn by pink, brown, and sand.
