Fig. 4.

(a) RMSFs of the SARS-CoV-2 nsp12s with and without Mg²⁺. (b) RMSFs of nsp12s of SARS-CoV and SARS-CoV-2 without Mg²⁺. Purple line, green line, orange line, blue line, and red line represent the NiRAN domain, interface domain, fingers domain, palm domain, and thumb domain, respectively. The regions highlighted in violet show residues in motif A–G, and the uppercase letters are the labels of these motifs. The brown and green rectangles show residues that have large differences in RMSF.