Table 1.
Studies reporting outcomes of carotid revascularization procedures in elderly ACS patients
| Study | Study aim/study design | Results | |
|---|---|---|---|
| Studies comparing different age groups | |||
| Halm et al. [16] (2009) | Analysis of the results of 9,308 CEAs by age (<70 years: 2,152 CEAs; 70–79 years: 4,958 CEAs; ≥80 years: 2,198 CEAs) | Ipsilateral stroke/death rates (≥80 vs. 70–79 years): 4.82% vs. 3.73%; P<0.02 | |
| Rajamani et al. [22] (2013) | Comparison of outcomes stratified by age (<75 vs. 75 to <80 vs. 80 to <85 vs. >85 years) among symptomatic (n=1,376) and asymptomatic (n=2,773) patients undergoing CEA | Overall mortality for patients <75 vs. >85 years: 0.1% vs. 1.7%; P=0.002 | |
| In-hospital death/stroke/MI for patients <75 vs. >85 years: 2.2% vs. 5.6%; P=0.003 | |||
| Schmid et al. [25] (2017) | Analysis of 142,074 CEAs (85,738 for ACS; 56,336 for symptomatic carotid stenosis) from the Statutory German Quality Assurance Database between 2009–2014 | Crude risk of any in-hospital stroke/death for ACS patients aged <65, 65–69, 70–74, 75–79, and ≥80 years: 1.0% vs. 1.3% vs. 1.3% vs. 1.5% vs. 1.9%, respectively (P<0.001 for trend) | |
| Studies reporting outcomes in the elderly | |||
| Rinckenbach et al. [27] (2007) | Evaluation of outcomes after CEA in 57 ACS patients ≥80 years old | Perioperative ipsilateral stroke/death rate: 8.8% | |
| Kaplan-Meier 5-year survival: 52% | |||
| De Rango et al. [21] (2012) | Assessment of the clinical relevance of carotid revascularization procedures in patients ≥80 years old (n=348 procedures in 323 patients; 179 ACS patients) | All-cause 5-year mortality: 65.4% | |
| All-cause 5-year mortality in ACS patients: 67.8% | |||
| Salomon du Mont et al. [24] (2014) | Overview of the results of 132 CEAs in 118 patients ≥80 years (50 CEAs on symptomatic; 82 CEAs on ACS patients) | Ipsilateral stroke/death rate for ACS patients: 4.88% | |
| Wach et al. [23] (2015) | Evaluation of CAS safety and efficacy in patients aged ≥90 years (n=21 CAS procedures in 20 patients; 11 symptomatic; 9 ACS patients [10 CAS procedures]) | Perioperative stroke rate for ACS patients: 10% | |
| 50% of ACS patients were alive at 47 months | |||
| Hobbs et al. [26] (2020) | Analysis of CEA outcomes offered to 33 ACS patients ≥90 years | 30-day mortality rate: 6.1% Median survival: 29.4 months | |
ACS, asymptomatic carotid stenosis; CEA, carotid endarterectomy; MI, myocardial infarction; CAS, carotid artery stenting.