Table 4.
Prognostic factors of patients with GIB after haplo-HSCT.
| Variables | Patients (n, %) | Univariate P value | Multivariate | |||
|---|---|---|---|---|---|---|
| Death (−) | Death(+) | HR | 95% | P value | ||
| Age > 30 | 54 (44.3) | 37 (56.1) | 0.045 | 1.427 | 0.833–2.444 | 0.195 |
| Male | 68 (55.7) | 43 (65.2) | 0.296 | |||
| Transplant complications prior to GIB | ||||||
| III–IV aGVHD | 60 (49.2) | 44 (66.7) | 0.004 | 2.302 | 1.340–3.952 | 0.003 |
| Extensive cGVHD | 11 (9.0) | 6 (9.1) | 0.566 | |||
| TMA | 2 (1.6) | 11 (16.7) | 0.000 | 5.539 | 2.745–11.179 | 0.000 |
| SOS | 0.120 | |||||
| DIC | 1 (0.8) | 7 (10.6) | 0.000 | 4.535 | 1.963–10.478 | 0.000 |
| AKI | 16 (13.1) | 22 (33.3) | 0.000 | 2.621 | 1.510–4.548 | 0.001 |
| Intestinal infection | 41 (33.6) | 21 (31.8) | 0.934 | |||
| CMV viremia | 67 (54.9) | 45 (68.2) | 0.087 | 1.306 | 0.749–2.277 | 0.346 |
| Gastrointestinal disease or bleeding before HSCT | 7 (5.7) | 12 (18.2) | 0.002 | 3.748 | 1.925–7.296 | 0.000 |
| Laboratory data at the occurrence of GIB | ||||||
| Hb < 80 g/L | 59 (48.4) | 38 (57.6) | 0.056 | 1.319 | 0.785–2.215 | 0.296 |
| Platelet count < 30 × 109/L | 58 (47.5) | 34 (51.5) | 0.421 | |||
| Platelet count < 20 × 109/L | 33 (27.0) | 26 (39.4) | 0.083 | 1.390 | 0.802–2.410 | 0.241 |
| Comorbidities | ||||||
| Viral hepatitis | 14 (11.5) | 8 (12.1) | 0.659 | |||
| Hypertension | 9 (7.4) | 11 (16.7) | 0.109 | |||
| Diabetes mellitus | 5 (4.1) | 5 (7.6) | 0.422 | |||
| Alcohol | 4 (3.3) | 2 (3.0) | 0.997 | |||
GIB gastrointestinal bleeding, aGVHD acute graft-versus-host disease, cGVHD chronic graft-versus-host disease, SOS sinusoidal obstruction syndrome, TMA thrombotic microangiopathy, DIC disseminated intravascular coagulation, AKI acute kidney injury, CMV cytomegalovirus, HSCT hematopoietic stem cell transplantation.