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. 2021 Apr 29;38(6):2779–2794. doi: 10.1007/s12325-021-01750-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Macroscopic and microscopic findings of Brunner’s gland hamartoma. Case 1. A 55-year-old male patient presented with abdominal discomfort and underwent endoscopic examination showing a polyp in the duodenal bulb. a Endoscopically resected specimen of about 1.5 × 0.8 × 0.7 cm in size. b Histological examination revealing massive hyperplasia of Brunner’s glands with focal dysplasia (hematoxylin and eosin, × 100). Case 2. A 60-year-old male patient presented with melena and underwent endoscopic examination showing a polyp in the duodenal bulb with bleeding. c Endoscopically resected specimen of about 3.5 × 2.0 × 1.0 cm in size. d Histological examination revealing massive hyperplasia of Brunner’s glands mixed with smooth muscle and infiltrating inflammatory cells (hematoxylin and eosin, × 100)