Why carry out this study?

Direct oral anticoagulants overcome almost all the limitations derived from the use of vitamin K antagonists, demonstrating better efficacy and safety in patients with non-valvular atrial fibrillation

Elderly patients were scarcely represented in pivotal randomized controlled trials with direct oral anticoagulants and therefore unmet clinical needs still exist

What was learned from the study?

This review article highlights eight main clinical areas of unmet needs in elderly patients. It also provides potential answers based on the results coming from randomized clinical trials, real-world data, and the authors’ clinical experience

A table summarizes unmet clinical needs and potential answers for the eight areas considered in the text