Table 5.
Haematological, biochemical, and serum electrolyte levels of patients
| Control (N = 22) | Centhaquine (N = 23) | |||||
|---|---|---|---|---|---|---|
| Day 1 (baseline) | Day 3 | Day 28 | Day 1 (baseline) | Day 3 | Day 28 | |
| Haematology | ||||||
| Haemoglobin (g/dl) | 9.38 ± 0.71 | 9.84 ± 0.33 | 12.26 ± 0.44 | 8.73 ± 0.55 | 8.71 ± 0.30 | 11.00 ± 0.38 |
| Haematocrit (%) | 28.79 ± 2.11 | 30.26 ± 1.00 | 38.01 ± 1.36 | 26.71 ± 1.81 | 26.43 ± 0.96 | 34.31 ± 1.16 |
| Red blood cells (mill/cumm) | 3.35 ± 0.23 | – | 4.44 ± 0.19 | 3.05 ± 0.20 | – | 4.04 ± 0.13 |
| White blood cells | 15.17 ± 1.22 | – | 8.65 ± 0.49 | 16.33 ± 1.40 | – | 8.37 ± 0.64 |
| Neutrophils (%) | 81.50 ± 2.21 | – | 65.18 ± 2.48 | 82.97 ± 2.27 | – | 68.46 ± 2.08 |
| Lymphocytes (%) | 12.96 ± 2.13 | – | 24.42 ± 1.97 | 12.33 ± 2.01 | – | 22.86 ± 2.02 |
| Monocytes (%) | 4.53 ± 0.63 | – | 5.84 ± 0.62 | 3.43 ± 0.60 | – | 5.55 ± 0.62 |
| Eosinophils (%) | 0.91 ± 0.24 | – | 4.35 ± 0.91 | 1.24 ± 0.29 | – | 2.93 ± 0.38 |
| Basophils (%) | 0.18 ± 0.10 | – | 0.22 ± 0.08 | 0.27 ± 0.13 | – | 0.33 ± 0.14 |
| Reticulocytes (%) | 2.39 ± 0.31 | – | 1.93 ± 0.25 | 2.26 ± 0.73 | – | 1.83 ± 0.23 |
| Mean corpuscular volume (fl) | 84.40 ± 2.68 | – | 86.13 ± 1.54 | 87.63 ± 1.47 | – | 85.74 ± 1.59 |
| Mean corpuscular haemoglobin (Pg) | 27.29 ± 1.11 | – | 27.86 ± 0.62 | 28.74 ± 0.56 | – | 27.48 ± 0.46 |
| Lipid profile | ||||||
| Triglyceride (mg/dl) | 109.42 ± 12.66 | – | 198.46 ± 25.92 | 151.88 ± 21.47 | – | 160.51 ± 10.04 |
| Total cholesterol (mg/dl) | 109.58 ± 10.71 | – | 156.96 ± 8.53 | 132.51 ± 14.92 | – | 152.25 ± 10.07 |
| High-density lipoprotein (mg/dl) | 30.68 ± 2.50 | – | 39.53 ± 2.64 | 34.13 ± 2.68 | – | 40.17 ± 6.79 |
| Low-density lipoprotein (mg/dl) | 63.26 ± 8.97 | – | 91.16 ± 7.56 | 73.30 ± 11.60 | – | 93.04 ± 8.44 |
| Very-low-density lipoprotein (mg/dl) | 22.70 ± 2.24 | – | 40.09 ± 5.16 | 31.03 ± 4.36 | – | 34.59 ± 3.38 |
| Kidney function | ||||||
| Serum creatinine (mg/dl) | 0.94 ± 0.10 | – | 0.57 ± 0.03 | 1.13 ± 0.10 | – | 0.75 ± 0.06 |
| Blood urea nitrogen (mg/dl) | 12.46 ± 1.06 | – | 8.85 ± 0.63 | 15.24 ± 1.61 | – | 12.64 ± 1.58 |
| Glomerular filtration rate (ml/min/1.73 m2) | 114.08 ± 10.47 | – | 171.48 ± 11.41 | 90.86 ± 9.72 | 139.97 ± 15.36 | |
| Liver function | ||||||
| Alanine aminotransferase (U/l) | 172.52 ± 67.80 | – | 37.37 ± 5.13 | 91.58 ± 34.12 | – | 39.77 ± 7.31 |
| Aspartate aminotransferase (U/l) | 211.55 ± 64.76 | – | 29.68 ± 2.51 | 111.02 ± 28.69 | – | 35.46 ± 7.51 |
| Serum bilirubin (mg/dl) | 0.82 ± 0.13 | – | 0.84 ± 0.17 | 1.22 ± 0.42 | – | 0.64 ± 0.10 |
| Alkaline phosphatase (IU/l) | 88.36 ± 10.57 | – | 179.22 ± 24.00 | 83.56 ± 10.51 | – | 195.45 ± 38.77 |
| Serum albumin (g/dl) | 3.04 ± 0.16 | – | 3.89 ± 0.18 | 3.04 ± 0.24 | – | 3.53 ± 0.23 |
| Coagulation parameters | ||||||
| Platelet count (/cumm) | 201.59 ± 16.78 | 162.80 ± 20.80 | 329.75 ± 31.49 | 262.74 ± 42.81 | 191.81 ± 33.10 | 308.70 ± 22.66 |
| Prothrombin time (S) | 18.55 ± 2.53 | 14.82 ± 0.52 | 14.15 ± 0.45 | 17.51 ± 2.06 | 15.71 ± 0.88 | 15.43 ± 0.73 |
| Fibrinogen value | 259.26 ± 20.64 | 392.92 ± 23.12 | 388.34 ± 34.87 | 306.47 ± 44.74 | 339.49 ± 30.89 | 361.48 ± 28.07 |
| International normalized ratio | 1.93 ± 0.50 | 1.25 ± 0.03 | 1.20 ± 0.03 | 1.40 ± 0.09 | 1.34 ± 0.08 | 1.23 ± 0.03 |
| Blood glucose (mg/dl) | 158.23 ± 19.73 | – | 114.38 ± 7.10 | 185.14 ± 24.95 | –- | 111.13 ± 7.92 |
| Serum electrolyte | ||||||
| Sodium (mmol/l) | 140.02 ± 0.80 | – | 136.87 ± 1.10 | 138.32 ± 1.02 | – | 137.26 ± 1.01 |
| Potassium (mmol/l) | 3.98 ± 0.15 | – | 4.29 ± 0.15 | 4.03 ± 0.14 | – | 4.19 ± 0.09 |
| Calcium (mmol/l) | 1.48 ± 0.14 | – | 1.99 ± 0.13 | 1.57 ± 0.14 | – | 1.86 ± 0.11 |
Data are presented as mean ± standard error of the mean