Fig. 2.

Fluvastatin treatment reduces tumor incidence, delays onset of tumor, and inhibits tumor growth in the SV40C3 TAg mouse model of breast cancer progression. a Fluvastatin treatment (10 mg/kg/day) for 16 weeks inhibited the percentage of mice that developed mammary tumors as determined by the macroscopic lesions at the time of necropsy at 22 weeks of age b and the average number of tumors per mouse relative to the vehicle control group after 16 weeks of treatment. c Fluvastatin treatment (10 mg/kg/day) for 16 weeks inhibited the average tumor weight per group d and delayed the average age at which tumors appear, as shown here as the % incidence of palpable tumor bearing mice during the course of study (12 week of age to 21 week age), relative to the vehicle control group. *p < 0.05