Fig. 3.

Fluvastatin treatment reduces total cholesterol in mouse mammary glands of SV40C3 TAg mice. a Bar diagram showing total serum cholesterol levels that did not change after 16-week treatment with fluvastatin (10 mg/kg/day), aspirin (20 mg/kg/day), or combined treatment relative to vehicle control. b, c Table and bar diagram (right side) showing HMGCR and AMPK mRNA levels in mammary tissue that did not change after 16-week or 10-day treatment with indicated drugs relative to vehicle control. The mean values were calculated by using the ΔΔCt method (as described previously [15]) after normalizing with ribosomal protein L19, which was set as 1. d, c Bar diagram showing total cholesterol levels before (in mouse serum) and after (in mouse serum and mammary tissue) short-term treatment with fluvastatin (10 mg/kg/day) relative to vehicle control. Values represent mean absolute cholesterol levels ± SEM. *p < 0.05