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. 2021 Apr 24;187(2):363–374. doi: 10.1007/s10549-021-06229-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Replenishing with the cholesterol biosynthesis pathway metabolite, GGPP, inhibits the fluvastatin-induced apoptosis in MCF10.AT1 cells. a Bar diagram showing apoptotic cell death in fluvastatin (10 µM)-treated cells that were completely rescued by cotreatment with isoprenoid GGPP or MVA, but not squalene. b Raw FACS plots for treatment groups as shown. *p < 0.05; **p < 0.01