The data presented provide real-world evidence on the management of mycosis fungoides (MF) in daily clinical practice through the application of chlormethine gel.

Patients with stage I–IIB MF who had varying treatment histories achieved complete responses after treatment with chlormethine gel.

Skin-related adverse events (AEs) were successfully managed through the use of topical emollients and steroids.

The occurrence of skin-related AEs did not impact the decision to remain on treatment.