Table 6.
Univariate analysis according to consensus radiologist assessment
| Imaging feature | Upgrade status | p-value | ||
|---|---|---|---|---|
| Overall | No-upgrade | Upgrade | ||
| BPE | 0.11 | |||
| Minimal | 21 (15) | 17 (15) | 4 (14) | |
| Mild | 56 (40) | 47 (42) | 9 (32) | |
| Moderate | 51 (37) | 36 (32) | 15 (54) | |
| Marked | 11 (7.9) | 11 (9.9) | 0 (0) | |
| FGT | 0.7 | |||
| Almost entirely fat | 1 (0.7) | 1 (0.9) | 0 (0) | |
| Scattered FGT | 37 (27) | 28 (25) | 9 (32) | |
| Heterogeneous FGT | 89 (64) | 71 (64) | 18 (64) | |
| Extreme FGT | 12 (8.6) | 11 (9.9) | 1 (3.6) | |
| Depth | > 0.9 | |||
| Anterior | 36 (26) | 28 (25) | 8 (29) | |
| Middle | 72 (52) | 58 (52) | 14 (50) | |
| Posterior | 31 (22) | 25 (23) | 6 (21) | |
| T2 signal intensity | 0.2 | |||
| Hypointense | 1 (0.7) | 0 (0) | 1 (3.6) | |
| Isointense | 111 (80) | 88 (79) | 23 (82) | |
| Hyperintense | 27 (19) | 23 (21) | 4 (14) | |
| DWI signal (75 lesions) | 0.6 | |||
| Homogeneous | 27 (36) | 23 (40) | 4 (24) | |
| Heterogeneous | 7 (9.3) | 5 (8.6) | 2 (12) | |
| Rim | 1 (1.3) | 1 (1.7) | 0 (0) | |
| No correlate | 40 (53) | 29 (50) | 11 (65) | |
| ADC signal (61 lesions) | 0.6 | |||
| Hyperintense | 3 (4.9) | 3 (6.4) | 0 (0) | |
| Hypointense | 9 (15) | 6 (13) | 3 (21) | |
| No correlate | 49 (80) | 38 (81) | 11 (79) | |
| BI-RADS | 0.7 | |||
| 3 | 10 (7.2) | 9 (8.1) | 1 (3.6) | |
| 4 | 129 (93) | 102 (92) | 27 (96) | |
| Enhancement type | 0.6 | |||
| Mass like | 71 (51) | 59 (53) | 12 (43) | |
| Non-mass like | 66 (47) | 50 (45) | 16 (57) | |
| Mixed | 2 (1.4) | 2 (1.8) | 0 (0) | |
| Shape (mass) | 0.12 | |||
| Oval | 16 (22) | 16 (26) | 0 (0) | |
| Round | 16 (22) | 12 (20) | 4 (33) | |
| Irregular | 41 (56) | 33 (54) | 8 (67) | |
| Margins (mass) | 0.6 | |||
| Circumscribed | 34 (47) | 30 (49) | 4 (33) | |
| Irregular | 32 (44) | 25 (41) | 7 (58) | |
| Spiculated | 7 (9) | 6 (10) | 1 (8.3) | |
| Enhancement (mass) | 0.5 | |||
| Homogeneous | 33 (45) | 29 (47) | 4 (33) | |
| Heterogeneous | 37 (50) | 30 (48) | 7 (58) | |
| Rim enhancement | 3 (4.1) | 2 (3.2) | 1 (9) | |
| Dark internal septation | 1 (1.4) | 1 (1.6) | 0 (0) | |
| Distribution (non-mass) | 0.2 | |||
| Focal | 25 (37) | 22 (42) | 3 (19) | |
| Linear | 23 (34) | 18 (35) | 5 (31) | |
| Segmental | 18 (26) | 11 (21) | 7 (44) | |
| Regional | 2 (2.9) | 1 (1.9) | 1 (6.2) | |
| Multiple regions | 0 (0) | 0 (0) | 0 (0) | |
| Diffuse | 0 (0) | 0 (0) | 0 (0) | |
| Enhancement (non-mass) | 0.9 | |||
| Homogeneous | 10 (15) | 7 (13) | 3 (19) | |
| Heterogeneous | 36 (53) | 28 (54) | 8 (50) | |
| Clumped | 22 (32) | 17 (33) | 5 (31) | |
| Clustered rings | 0 (0) | 0 (0) | 0 (0) | |
| DCE (kinetics)* | 0.2 | |||
| Progressive | 54 (40) | 47 (44) | 7 (25) | |
| Plateau | 63 (47) | 47 (44) | 16 (57) | |
ADC apparent diffusion coefficient, BI-RADS breast imaging-reporting & data system, BPE background parenchymal enhancement, DCE dynamic contrast-enhanced, DWI diffusion-weighted imaging, FGT fibroglandular tissue
*Kinetic analysis was performed only by R1