. 2021 May 19;38(6):3325–3341. doi: 10.1007/s12325-021-01717-7

Table 2.

Estimated EQ-5D least-squares mean utility scores over time by age group

	50–59 YOA N = 137			60–64 YOA N = 90			65–69 YOA N = 100			70–79 YOA N = 158			≥ 80 YOA N = 60			Overall ≥ 50 YOA N = 545
	n	Mean	SE	n	Mean	SE	n	Mean	SE	N	Mean	SE	n	Mean	SE	n	Mean	SE
All patients with HZ (n = 545)
Day 0	69	0.670	0.037	52	0.706	0.043	48	0.700	0.044	91	0.671	0.032	39	0.494	0.050	299	0.661	0.018
Day 15	49	0.814	0.036	40	0.728	0.041	47	0.795	0.038	69	0.689	0.031	25	0.638	0.052	230	0.740	0.017
Day 30	108	0.875	0.023	81	0.835	0.027	86	0.851	0.026	131	0.759	0.021	47	0.694	0.036	453	0.811	0.012
Day 60	114	0.921	0.021	78	0.892	0.025	90	0.898	0.024	141	0.831	0.019	48	0.709	0.032	471	0.864	0.011
Day 90	107	0.914	0.021	73	0.855	0.025	81	0.889	0.024	132	0.892	0.019	48	0.752	0.031	441	0.876	0.010
Day 0–30^a		0.787	0.023		0.756	0.027		0.782	0.027		0.706	0.021		0.609	0.034		0.738	0.012
Disutility (day 0–30)^b		0.127			0.099			0.107			0.186			0.143			0.138
QALY loss (day 0–30)^c		0.010			0.008			0.009			0.015			0.012			0.011
Patients without PHN (n = 520)
Day 0	66	0.677	0.038	48	0.708	0.044	45	0.726	0.045	86	0.671	0.033	33	0.512	0.054	278	0.671	0.019
Day 15	49	0.817	0.035	36	0.767	0.042	45	0.802	0.038	64	0.716	0.031	22	0.642	0.054	216	0.759	0.017
Day 30	105	0.876	0.023	77	0.859	0.027	83	0.859	0.026	126	0.764	0.021	41	0.729	0.037	432	0.823	0.012
Day 60	111	0.924	0.021	72	0.901	0.026	87	0.905	0.024	136	0.838	0.019	42	0.714	0.034	448	0.871	0.011
Day 90	105	0.917	0.020	67	0.872	0.025	77	0.903	0.023	127	0.899	0.018	42	0.771	0.032	418	0.888	0.010
Day 0–30^a		0.790	0.023		0.778	0.028		0.796	0.027		0.717	0.021		0.627	0.036		0.751	0.012
Disutility (day 0–30)^b		0.127			0.094			0.107			0.182			0.144			0.137
QALY loss (day 0–30)^c		0.010			0.008			0.009			0.015			0.012			0.011

EQ-5D EuroQoL-5 Dimension questionnaire, HZ herpes zoster, N total number of patients in each age group, n number of patients with evaluable questionnaires, PHN postherpetic neuralgia, QALY quality-adjusted life-year, SE standard error, YOA years of age

^aDay 0–30 is the estimated least-squares (LS) mean utility score averaged over days 0–30

^bDisutility is calculated using the estimated LS mean values at day 90 as the normal or baseline utility score and using the difference between this and the LS mean utility score averaged over days 0–30

^cQALY loss calculated as disutility value multiplied by (length of period in days)/(number of days in year), i.e., 30/365