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. 2021 Jun 9;11:10867. doi: 10.1038/s41598-021-90084-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic biomarker differences between menopausal groups. (a) Surface maps of regional CMRglc differences. (b) MRI slice overlays and plots representing CMRglc in temporal and parietal regions. (c) Surface maps of regional CBF differences. (d) MRI slice overlays and plots representing CBF extracted in temporal and parietal clusters. (e) Slice overlays depicting the overlap between CMRglc (green to red scale) and CBF (blue to green scale) effects. (f) In (a, c), SPMs are represented on modality-specific color-coded scales with corresponding p values. In (e), Z scores are reported to enable multi-modality comparisons. In (b, d), values are mean (SE). Results are adjusted by age and global activity. Abbreviations CBF, cerebral blood flow; CMRglc, cerebral glucose metabolism; PERI, peri-menopause; POST, post-menopause; PRE, pre-menopause; SPMs, statistical parametric maps.