Table 1.
Participants’ characteristics by menopause status.
| Pre-menopausal group | Peri-menopausal group | Post-menopausal group | |
|---|---|---|---|
| Clinical and demographic measures | |||
| N | 30 | 57 | 74 |
| Age, years, range | 44 (4), 40–53 | 50 (4), 41–60 | 57 (4)*, 46–65 |
| Education, years | 17 (3) | 17 (2) | 17 (2) |
| Ethnicity, % White | 80 | 77 | 89 |
| MMSE score | 29 (1) | 29 (1) | 29 (1) |
| APOE ε4 carriers, % positive | 43 | 33 | 48 |
| Hysterectomy status, % positive | 0 | 6 | 19 |
| Menopausal hormonal therapy | |||
| % Current users | 0 | 13 | 32 |
| % Past users | 0 | 2 | 4 |
| Cognitive measures | |||
| Global cognition, mean (SE) | − 0.11 (0.17) | − 0.02 (0.09) | 0.06 (0.11) |
| Adjusted by APOE-4 status | − 0.09 (0.17) | − 0.03 (0.09) | 0.06 (0.11) |
| Memory, mean (SE) | 0.05 (0.20) | 0.06 (0.11) | 0.02 (0.13) |
| Adjusted by APOE-4 status | 0.07 (0.21) | 0.04 (0.11) | 0.02 (0.13) |
Clinical measures are means (SD), unless otherwise specified. Cognitive measures are age and education-adjusted means (SE).
*Different from PRE, p < 0.05.