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. 2021 Jun 9;11:10867. doi: 10.1038/s41598-021-90084-y

Table 3.

Regions-of-interest (ROI) measures by age-matched male group comparisons.

PRE MALEPRE PERI MALEPERI POST MALEPOST
ATP/PCr measures
Anterior cingulate cortex 1.06 (0.07) 1.11 (0.07) 1.10 (0.04) 1.12 (0.05) 1.12 (0.04) 1.12 (0.05)
Adjusted by APOE-4 status 1.05 (0.07) 1.12 (0.07) 1.11 (0.04) 1.10 (0.05) 1.11 (0.04) 1.13 (0.05)
Insula 1.21 (0.06) 1.29 (0.07) 1.24 (0.04) 1.24 (0.04) 1.26 (0.03)* 1.21 (0.05)
Adjusted by APOE-4 status 1.20 (0.06) 1.30 (0.06) 1.24 (0.04) 1.23 (0.04) 1.27 (0.03)* 1.22 (0.05)
Inferior parietal lobule 0.78 (0.07) 0.85 (0.08) 0.76 (0.04) 0.84 (0.04) 0.83 (0.03) 0.86 (0.04)
Adjusted by APOE-4 status 0.77 (0.08) 0.86 (0.08) 0.76 (0.04) 0.84 (0.04) 0.83 (0.03) 0.86 (0.04)
Middle temporal gyrus 1.10 (0.04) 1.17 (0.05) 1.15 (0.02) 1.12 (0.3) 1.19 (0.02)* 1.10 (0.03)
Adjusted by APOE-4 status 1.10 (0.04) 1.18 (0.04) 1.15 (0.02) 1.12 (0.3) 1.19 (0.02)* 1.10 (0.03)
Medial temporal lobe 1.16 (0.05) 1.24 (0.05) 1.22 (0.03) 1.20 (0.04) 1.21 (0.03) 1.19 (0.04)
Adjusted by APOE-4 status 1.15 (0.05) 1.26 (0.05) 1.22 (0.03) 1.20 (0.04) 1.22 (0.03) 1.19 (0.04)
Medial frontal gyrus 1.05 (0.06) 0.99 (0.06) 1.04 (0.03) 0.98 (0.04) 1.07 (0.03)* 0.95 (0.04)
Adjusted by APOE-4 status 1.04 (0.06) 1.01 (0.06) 1.05 (0.03) 0.97 (0.04) 1.07 (0.03)* 0.96 (0.04)
Superior frontal gyrus 0.95 (0.05) 0.86 (0.06) 0.94 (0.03)* 0.84 (0.03) 0.96 (0.03)* 0.83 (0.04)
Adjusted by APOE-4 status 0.94 (0.05) 0.87 (0.05) 0.95 (0.03)* 0.84 (0.04) 0.96 (0.03)* 0.84 (0.04)
Amyloid-β load
AD-mask SUVR 1.01 (0.05) 0.92 (0.05) 1.20 (0.05)* 0.92 (0.06) 1.29 (0.05)* 0.93 (0.06)
Adjusted by APOE-4 status 1.01 (0.05) 0.92 (0.05) 1.21 (0.05)* 0.91 (0.06) 1.29 (0.05)* 0.93 (0.06)
AD-mask SUVR by APOE-4 status
APOE-4− 0.94 (0.07) 0.86 (0.07) 1.14 (0.06) 0.88 (0.08) 1.32 (0.07)* 0.93 (0.09)
APOE-4+ 1.07 (0.07) 0.96 (0.08) 1.32 (0.09)* 0.93 (0.10) 1.25 (0.05)* 0.95 (0.10)

MALEPRE, males age-matched to PRE; MALEPERI, males age-matched to PERI; MALEPOST, males age-matched to POST; PERI, peri-menopausal group; POST, post-menopausal group; PRE, pre-menopausal group.

Values are means (SE).

*Different from age-matched males, p < 0.05.