Skip to main content
. 2021 Jun 9;12:3495. doi: 10.1038/s41467-021-23903-5

Fig. 5. Time-dependent increased proliferation of dopaminergic cells in MPS-IIIA mesencephalic neurons.

Fig. 5

a, b Primary cultures of mesencephalic neurons reproduce the progression of the TH phenotype in vitro, showing an increase in dopaminergic cell density at DIV4. However, at DIV14, while in WT cells there was a time-dependent increase, MPS-IIIA cells showed a decrease of TH+ cells density (scale bar: 75 µm). c MAP2 + neurons were not changed at DIV4 and DIV7, while were reduced at DIV14 in MPS-IIIA cells. Histograms represent mean ± S.E.M. *p < 0.05 vs WT, between groups; #p < 0.05 vs WT, within groups; °p < 0.05 vs MPS-IIIA, within groups.