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. 2021 Jun 9;12(6):597. doi: 10.1038/s41419-021-03866-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Bioinformation analysis the circC16orf62(circRNA_0005699) expression in the HCC tissues and adjacent tissue based on the GEO database (GSE97332). B q-PCR analysis the expression level of circC16orf62 in tumor tissues and adjacent normal tissues. C FISH assay was used to examine the expression of circC16orf62 in the HCC tissue, the scale bar represents 50 µm. D Kaplan–Meier analysis showed that the expression of circC16orf62, was predictive of overall survival in HCC. E qRT-PCR to detect the expression of circC16orf62 in six human HCC cell lines and one human non-cancerous cell line (LO-2). Data are shown as the mean ± standard deviation of three independent experiments.*P < 0.05 was regarded as statistically significant.