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. 2021 Jun 9;12(6):597. doi: 10.1038/s41419-021-03866-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Bioinformatic analysis of the potential target gene by prediction software(PicTar, miRTargetbase, Targetscan, miRDB). B TACG data base analysis of the expression level of PTK2 in HCC. C The person analysis the miRNA-138-5p and PTK2 expression correlation in HCC tissues. D, E The q-RT-PCR and western-blot assay analysis the PTK2 expression in miRNA-138-5p inhibition and overexpressed HCC cells. F The bioinformation analysis the binding site of miRNA-138-5p and PTK2. G, H The luciferase activity assay was used to verify the combination of miRNA-138-5p and PTK2. I The western blot analysis miRNA-138-5p targets the PTK2 expression involved in PI3K/AKT signal pathway. Data are shown as the mean ± standard deviation of three independent experiments. *P < 0.05was regarded as statistically significant.