Table 3.
List of solute carrier genes differentially expressed in rat retina and/or brain microvessels vs. retina and brain tissue samples.
| Symbol | RMVs | RT | RMVs. vs. RT | BMVs | BT | BMVs. vs. BT | RMVs. vs. BMVs | |||
|---|---|---|---|---|---|---|---|---|---|---|
| FC | adj. P | FC | adj. P | FC | adj. P | |||||
| Slc2a1 | 13.4 ± 0.05 | 11.8 ± 0.03 | 3.0 | 3E-22 | 13.5 ± 0.03 | 11.1 ± 0.03 | 5.5 | 5E-31 | -1.1 | 2E-01 |
| Slc2a4 | 7.4 ± 0.08 | 6.3 ± 0.07 | 2.1 | 1E-10 | 8.4 ± 0.07 | 6.2 ± 0.13 | 4.5 | 1E-22 | -2.0 | 7E-10 |
| Slc2a12 | 7.5 ± 0.13 | 6.7 ± 0.13 | 1.7 | 1E-04 | 10.2 ± 0.04 | 7.1 ± 0.1 | 8.7 | 3E-23 | -6.4 | 1E-19 |
| Slc3a2 | 11.1 ± 0.07 | 10.6 ± 0.06 | 1.3 | 5E-05 | 11.6 ± 0.04 | 10.3 ± 0.04 | 2.5 | 5E-20 | -1.4 | 2E-06 |
| Slc5a5 | 6.8 ± 0.11 | 6.4 ± 0.16 | 1.4 | 3E-02 | 8.6 ± 0.06 | 6.3 ± 0.07 | 4.9 | 9E-18 | -3.5 | 3E-13 |
| Slc6a20 | 6.2 ± 0.04 | 6.2 ± 0.28 | 1.0 | 1E + 00 | 10.1 ± 0.09 | 7.2 ± 0.15 | 7.8 | 2E-19 | -15.2 | 6E-24 |
| Slc7a1 | 11.9 ± 0.12 | 8.6 ± 0.2 | 10.0 | 9E-23 | 12.5 ± 0.07 | 9.5 ± 0.04 | 8.0 | 1E-21 | -1.5 | 1E-02 |
| Slc7a2 | 9 ± 0.07 | 8.2 ± 0.16 | 1.7 | 3E-06 | 10.8 ± 0.08 | 8.8 ± 0.06 | 3.9 | 1E-18 | -3.5 | 2E-16 |
| Slc7a5 | 11.8 ± 0.06 | 11 ± 0.07 | 1.7 | 7E-07 | 12.3 ± 0.04 | 9.7 ± 0.08 | 5.7 | 4E-25 | -1.4 | 4E-03 |
| Slc7a15 | 8.2 ± 0.13 | 6.3 ± 0.14 | 3.6 | 2E-16 | 8.6 ± 0.09 | 6.3 ± 0.07 | 5.0 | 4E-21 | -1.3 | 2E-02 |
| Slc8b1 | 6.9 ± 0.05 | 6 ± 0.05 | 1.8 | 1E-07 | 8 ± 0.08 | 6.6 ± 0.11 | 2.7 | 1E-14 | -2.2 | 8E-11 |
| Slc9a3r2 | 11 ± 0.08 | 8 ± 0.13 | 7.9 | 5E-31 | 11.7 ± 0.05 | 8.7 ± 0.06 | 7.7 | 3.E-31 | -1.6 | 7E-07 |
| Slc10a3 | 9.1 ± 0.12 | 7.5 ± 0.2 | 3.2 | 8E-08 | 9.8 ± 0.17 | 7.3 ± 0.24 | 5.4 | 7E-13 | -1.5 | 4E-02 |
| Slc10a7 | 9 ± 0.08 | 8.2 ± 0.09 | 1.7 | 2E-07 | 9 ± 0.05 | 7.2 ± 0.06 | 3.5 | 1E-19 | -1.0 | 8E-01 |
| Slc12a4 | 8.2 ± 0.18 | 7.4 ± 0.06 | 1.8 | 2E-07 | 9.4 ± 0.04 | 8 ± 0.09 | 2.6 | 9E-14 | -2.3 | 2E-11 |
| Slc12a7 | 9.5 ± 0.06 | 9 ± 0.05 | 1.4 | 1E-04 | 10.1 ± 0.08 | 7 ± 0.09 | 8.8 | 4E-33 | -1.5 | 7E-07 |
| Slc12a8 | 5.9 ± 0.08 | 5.8 ± 0.13 | 1.1 | 6E-01 | 6.7 ± 0.1 | 5.7 ± 0.06 | 2.1 | 5E-09 | -1.7 | 4E-06 |
| Slc13a4 | 6.5 ± 0.11 | 6.3 ± 0.1 | 1.1 | 5E-01 | 10.6 ± 0.09 | 7.7 ± 0.05 | 7.6 | 1E-23 | -18.1 | 4E-30 |
| Slc15a3 | 7.8 ± 0.06 | 6.2 ± 0.11 | 2.9 | 1E-11 | 8.8 ± 0.1 | 7.5 ± 0.05 | 2.5 | 5E-10 | -2.0 | 5E-07 |
| Slc16a1 | 11.4 ± 0.11 | 10.4 ± 0.05 | 2.1 | 1E-04 | 9.7 ± 0.18 | 8.7 ± 0.09 | 2.0 | 2E-04 | 3.4 | 4E-09 |
| Slc16a2 | 8.6 ± 0.13 | 7.3 ± 0.09 | 2.4 | 6E-13 | 10.9 ± 0.03 | 8.5 ± 0.1 | 5.1 | 6E-24 | -4.9 | 9E-23 |
| Slc16a4 | 7.4 ± 0.15 | 4.8 ± 0.11 | 6.1 | 3E-20 | 8.4 ± 0.1 | 5.1 ± 0.07 | 9.9 | 2E-25 | -2.0 | 1E-06 |
| Slc16a11 | 6.3 ± 0.06 | 6.2 ± 0.05 | 1.0 | 9E-01 | 7.7 ± 0.06 | 6.3 ± 0.05 | 2.6 | 1E-13 | -2.7 | 1E-13 |
| Slc16a12 | 6 ± 0.17 | 5.2 ± 0.15 | 1.7 | 2E-03 | 7.9 ± 0.04 | 5.2 ± 0.17 | 6.8 | 1E-17 | -3.9 | 1E-11 |
| Slc16a13 | 7.1 ± 0.16 | 6.4 ± 0.09 | 1.6 | 2E-05 | 8.3 ± 0.05 | 6.9 ± 0.07 | 2.7 | 4E-14 | -2.4 | 2E-11 |
| Slc19a3 | 10.4 ± 0.16 | 6.7 ± 0.12 | 13.1 | 4E-20 | 11 ± 0.12 | 7.5 ± 0.16 | 11.2 | 1E-19 | -1.5 | 3E-02 |
| Slc22a5 | 8.7 ± 0.11 | 7 ± 0.14 | 3.4 | 1E-11 | 9.1 ± 0.14 | 7.1 ± 0.11 | 3.9 | 8E-14 | -1.3 | 2E-01 |
| Slc22a6 | 6.3 ± 0.08 | 6.2 ± 0.15 | 1.1 | 7E-01 | 10.2 ± 0.11 | 6.7 ± 0.05 | 11.5 | 2E-23 | -14.9 | 7E-25 |
| Slc22a8 | 9.7 ± 0.14 | 7 ± 0.28 | 6.3 | 2E-12 | 11.5 ± 0.08 | 7.8 ± 0.03 | 12.6 | 5E-18 | -3.5 | 1E-07 |
| Slc22a18 | 7.6 ± 0.07 | 6.2 ± 0.09 | 2.7 | 6E-12 | 8.5 ± 0.04 | 6 ± 0.13 | 5.9 | 3E-22 | -1.9 | 1E-06 |
| Slc25a2 | 7.6 ± 0.13 | 7.3 ± 0.13 | 1.2 | 4E-01 | 7.2 ± 0.1 | 5.9 ± 0.26 | 2.5 | 8E-08 | 1.3 | 1E-01 |
| Slc25a35 | 10.7 ± 0.11 | 10.6 ± 0.05 | 1.1 | 6E-01 | 9.6 ± 0.06 | 8 ± 0.08 | 3.2 | 2E-19 | 2.1 | 5E-12 |
| Slc25a45 | 7.2 ± 0.16 | 6 ± 0.15 | 2.3 | 4E-08 | 8.4 ± 0.1 | 6.1 ± 0.12 | 4.9 | 1E-17 | -2.3 | 7E-08 |
| Slc26a10 | 6.4 ± 0.07 | 5.9 ± 0.07 | 1.4 | 2E-04 | 9.2 ± 0.06 | 6.1 ± 0.06 | 8.8 | 6E-31 | -7.1 | 1E-28 |
| Slc28a3 | 6.8 ± 0.11 | 5.9 ± 0.08 | 1.9 | 1E-07 | 7.5 ± 0.16 | 5.8 ± 0.05 | 3.2 | 3E-16 | -1.6 | 2E-05 |
| Slc30a1 | 9.2 ± 0.11 | 7.7 ± 0.08 | 2.8 | 5E-15 | 10.2 ± 0.04 | 8.1 ± 0.06 | 4.1 | 6E-21 | -2.0 | 2E-09 |
| Slc30a10 | 7.4 ± 0.05 | 6.6 ± 0.08 | 1.8 | 4E-07 | 8.7 ± 0.06 | 7.3 ± 0.05 | 2.6 | 9E-14 | -2.4 | 1E-11 |
| Slc31a1 | 10.8 ± 0.09 | 9.8 ± 0.08 | 2.0 | 1E-11 | 11.1 ± 0.07 | 9.7 ± 0.02 | 2.6 | 6E-17 | -1.3 | 1E-02 |
| Slc31a2 | 8.9 ± 0.06 | 8.7 ± 0.05 | 1.2 | 6E-02 | 7.5 ± 0.04 | 6.3 ± 0.06 | 2.3 | 3E-15 | 2.7 | 4E-17 |
| Slc35f2 | 9.3 ± 0.16 | 6.8 ± 0.13 | 5.5 | 7E-16 | 9.7 ± 0.2 | 7.1 ± 0.12 | 6.0 | 3E-17 | -1.3 | 2E-01 |
| Slc38a5 | 9.6 ± 0.19 | 6.1 ± 0.1 | 11.1 | 3E-18 | 10.4 ± 0.12 | 6.3 ± 0.16 | 17.0 | 6E-22 | -1.8 | 5E-03 |
| Slc38a11 | 6.6 ± 0.1 | 5.8 ± 0.07 | 1.7 | 3E-05 | 7.2 ± 0.07 | 5.8 ± 0.08 | 2.7 | 3E-12 | -1.5 | 8E-04 |
| Slc39a1 | 8.9 ± 0.05 | 8.1 ± 0.05 | 1.8 | 2E-09 | 9.3 ± 0.05 | 8.2 ± 0.09 | 2.1 | 3E-13 | -1.3 | 4E-03 |
| Slc39a4 | 6.5 ± 0.07 | 6.1 ± 0.15 | 1.3 | 5E-02 | 7.3 ± 0.08 | 5.8 ± 0.11 | 2.8 | 5E-14 | -1.8 | 1E-06 |
| Slc39a8 | 9.6 ± 0.11 | 6.6 ± 0.2 | 8.3 | 9E-20 | 10 ± 0.11 | 6.8 ± 0.22 | 9.7 | 8E-22 | -1.3 | 1E-01 |
| Slc39a10 | 11.5 ± 0.11 | 9.5 ± 0.06 | 4.0 | 5E-18 | 12.3 ± 0.06 | 10.9 ± 0.04 | 2.6 | 6E-13 | -1.7 | 6E-06 |
| Slc40a1 | 10.8 ± 0.22 | 6.8 ± 0.17 | 16.0 | 9E-22 | 11.8 ± 0.08 | 8 ± 0.09 | 13.9 | 2E-21 | -2.0 | 3E-04 |
| Slc43a1 | 6.9 ± 0.14 | 5.1 ± 0.11 | 3.6 | 2E-13 | 7.5 ± 0.09 | 5.5 ± 0.17 | 4.1 | 1E-15 | -1.6 | 2E-03 |
| Slc50a1 | 9.5 ± 0.02 | 8.5 ± 0.08 | 2.0 | 1E-15 | 10.2 ± 0.04 | 8.6 ± 0.04 | 2.9 | 3E-24 | -1.5 | 3E-09 |
| Slc52a2 | 8.5 ± 0.05 | 7.9 ± 0.06 | 1.5 | 2E-04 | 8.8 ± 0.07 | 6.9 ± 0.05 | 3.6 | 1E-17 | -1.2 | 2E-01 |
| Slc52a3 | 9.4 ± 0.14 | 6.3 ± 0.05 | 8.5 | 4E-26 | 10.7 ± 0.04 | 6.8 ± 0.05 | 15.5 | 2E-31 | -2.5 | 6E-12 |
| Slco1a2 | 11.4 ± 0.11 | 7.5 ± 0.13 | 14.6 | 2E-24 | 12.1 ± 0.02 | 8.6 ± 0.08 | 11.5 | 3E-23 | -1.7 | 1E-03 |
| Slco1c1 | 12.8 ± 0.11 | 9.5 ± 0.06 | 9.7 | 2E-17 | 13.3 ± 0.03 | 10.7 ± 0.04 | 5.9 | 5E-14 | -1.5 | 8E-02 |
| Slco2a1 | 8.1 ± 0.13 | 5.7 ± 0.08 | 5.5 | 5E-13 | 7.6 ± 0.14 | 5.6 ± 0.12 | 4.2 | 3E-11 | 1.4 | 1E-01 |
| Slco2b1 | 9.2 ± 0.1 | 7.1 ± 0.08 | 4.6 | 4E-22 | 10.5 ± 0.01 | 8.1 ± 0.07 | 5.2 | 3E-24 | -2.4 | 1E-12 |
| Slco3a1 | 9.9 ± 0.05 | 8.3 ± 0.09 | 3.1 | 9E-21 | 10.3 ± 0.06 | 9.1 ± 0.1 | 2.3 | 2E-16 | -1.4 | 2E-04 |
Results are mean ± SEM of log2 transformed microarray intensity values (n = 6). RMVs, retinal microvessels; RT, retinal tissue; BMVs, brain microvessels; BT, brain tissue; FC, fold change; adj. P, false discovery rate adjusted p value.SLC, solute carrier.