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. 2021 Jun 9;11:12198. doi: 10.1038/s41598-021-91800-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Violin plot. The PAC distribution is presented by age and gender. The PAC burden increased with age (p for trend < 0.05), and similar distribution across all age bracket was found in both gender. The white bar in each violin plot presents interquartile range, and the central black horizontal line is median. The black lines stretched from the bar are the lower and upper adjacent values defined as first quartile − 1.5 IQR and third quartile + 1.5 interquartile range respectively. The colored area is the density plot, and the width suggests the frequency.