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. 2021 Jun 9;4:706. doi: 10.1038/s42003-021-02224-9

Fig. 4. Changes in PTA hearing thresholds by age for carriers of rare ARHI variants in Mendelian deafness genes.

Fig. 4

Effects of variants in a LOXHD1, b MPZL2, c SLC4A11, d SLC26A5, and e TMPRSS3 are shown. In a and b, the average PTA in the DHS dataset are represented with gray dots for non-carriers and orange dots for heterozygotes and the PTA hearing thresholds of the homozygous carriers in DHS and NIHSI datasets are represented with red squares. In c, d, and e, the average PTA of non-carriers in the DHS dataset are represented with gray dots and the PTA hearing threshold of the heterozygous carriers in DHS and NIHSI datasets by yellow squares. The dashed red lines are linear regression lines of best fit and the dashed yellow and grey lines are polynomial regression lines of best fit. The gray vertical lines represent 95% confidence intervals. A figure for TBC1D24 is not included because the variant was detected in UKB dataset only and therefore audiometric measures are not available for the carriers.