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. 2021 Jun 9;11:12225. doi: 10.1038/s41598-021-90833-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of channel- and cell-type specific responses in PREDICT96 co-cultures. (A) Select data shown from 16-plex Luminex kit run on media collected from EC and PC channels after 24 h. Note that some secreted factors are expressed in both channels while others are differentially expressed in EC or PC channels. (B) Gene expression for cells isolated from EC and PC channels of devices show that EC markers are significantly enriched in EC channels, while PC markers are significantly enriched in PC channels. Note that IL-6 is expressed by both cell types (secreted and gene). Enrichment of EC markers in the EC channel was significantly decreased in co-culture compared to mono-culture, indicated potential inter-channel crosstalk.