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. 2021 Apr 29;21:367–376. doi: 10.1016/j.omto.2021.04.011

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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E2F1 is highly expressed in both NSCLC tissues and cells

(A) Heatmap of the expression of highly expressed genes in the NSCLC-related microarray GEO: GSE74706. (B) Venn map of the intersection of upregulated genes of in the GEO: GSE74706 microarray, human transcription factors from Cistrome, and disease-related genes from GeneCards. (C) The interaction genes of EZH2 and E2F1 predicted by GeneMANIA. (D) Boxplot of E2F1 expression in NSCLC and normal tissues in the GEO: GSE74706 microarray. (E) Boxplot of E2F1 expression in lung adenocarcinoma tissues and adjacent normal tissues retrieved from TCGA database. (F) qRT-PCR measurement of the expression of E2F1 in NSCLC cell lines (A549, NCI-H1299, NCI-H23, NCI-H460) and human lung epithelial cell line 16HBE. (G) Western blot measurement of the expression of E2F1 in NSCLC cell lines (A549, NCI-H1299, NCI-H23, NCI-H460) and human lung epithelial cell line 16HBE. ∗p < 0.05 versus data regarding 16HBE cells. One-way ANOVA with Tukey’s post hoc test was applied for comparison among multiple datasets. Each experiment was conducted in triplicates.