Fig. 2.
Influence of ETA and ETB inhibition on myogenic tone in PCAs from young and aged Fischer 344 rats. a Myogenic tone in the PCAs of young rats in the presence (n = 7) or absence (n = 10) of the ETA antagonist BQ-123 (1 μM). b Myogenic tone in the PCAs of aged rats in the presence (n = 5) or absence (n = 9) of the ETA antagonist BQ-123 (1 μM). c Myogenic tone in the PCAs of young rats in the presence (n = 6) or absence (n = 9) of the ETB antagonist BQ-778 (1 μM). d Myogenic tone in the PCAs of aged rats in the presence (n = 6) or absence (n = 9) of the ETB antagonist BQ-778 (1 μM). * P < 0.05 vs. antagonist treatment at each pressure point. Significance was determined using repeated unpaired t tests with Holm-Sidak correction for multiple comparisons at each pressure point