Fig. 5.
Influence of ETA and ETB inhibition of myogenic tone in PCAs from wild-type and ETB-KO rats. Experiments were conducted after vessels were treated with either the ETA selective antagonist BQ-123 (1 μM) or the ETB selective antagonist BQ-788 (1 μM). a Myogenic tone in ETB-KO rat PCAs in the presence (n = 5) or absence (n = 6) of BQ-788. b Myogenic tone in ETB-KO rat PCAs in the presence (n = 5) or absence (n = 6) of BQ-123. c Myogenic tone in wild-type rat PCAs in the presence (n = 3) or absence (n = 5) of BQ-788. d Myogenic tone in wild-type rat PCAs in the presence (n = 4) or absence (n = 5) of BQ-123. * P < 0.05 vs. antagonist treatment at each pressure point. Significance was determined using repeated unpaired t tests with Holm-Sidak correction for multiple comparisons at each pressure point