Table 1.
Effect of rapamycin on lifespan of various strains of mice
| Mouse strain | Age started | Rapa dose | Increase in life span | Reference |
|---|---|---|---|---|
| UM-HET3 | 19 months | 14 ppm* | 9% M–14% F | [6] |
| C57BL/6Nia | 22–24 months | 4 mg/kg i.p.+ | > 100% M | [138] |
| UM-HET3 | 9 months | 14 ppm* | 10% M–18% F | [17] |
| 129/Sv | 2 months | 1.5 mg/kg s.c.^ | 10% F | [40] |
| C57BL/6 | 4, 13, and 20 months | 14 ppm* | 11% M | [79] |
| UM-HET3 | 9 months | 4.7, 14, and 42 ppm* | 3–23% M to 16–26% F | [19] |
| C57BL/6J | 4 months | 14 ppm* | 11% M–16% F | [16] |
| C57BL/6Nia | 19 months | 14 ppm* | 0% M–6% F | [139] |
| 129/Sv × C57BL/6 | 2 months | 14 ppm* | 12% M–21% F | [38] |
| C57BL/6Nia | 20 months |
126 ppm* 8 mg/kg i.p. daily# |
45% M–39% F 61% M–0% F |
[20] |
| C57BL/6J | 20 months | 2 mg/kg i.p.@ | 13% F | [10] |
| UM-HET3 | 9 months | 14 ppm* + metformin* | 23% M–23% F | [140] |
| C57BL/6 × C3H | 20–23 months | 4 mg/kg i.p.++ | 10% M–22%F | [30] |
| UM-HET3 | 9 months | 4.7, 14, and 42 ppm* | 16, 21, 26% F | [131] |
| C57BL/6 | 3 months | 42 ppm* | 58% M and F | [29] |
*Rapamycin given in the diet
^Rapamycin given for 2 weeks and then not given rapamycin for 2 weeks
#Rapamycin given for only 3 months
@Rapamycin given 5 days/week
+Rapamycin given every other day for 6 weeks
++Rapamycin given every other day