Table 7.
Effect of rapamycin on cell senescence
| Source | Cell type | Effect of rapamycin treatment | Reference |
|---|---|---|---|
| K5rtTA/tet-Wnt1 mice (in vivo) | Epithelial | Reduced number of senescent cells induced in mice by genetically by Wnt induction. | [109] |
|
Human (cell lines) |
ARPE-19, HT-p21, and HT1080 | Prevented senescence induced by H2O2, p21, and butyrate. | [173] |
| Rodent | Fibroblast | Modest decrease in senescence induced by butyrate but prevented loss of proliferation. | [173] |
| Human |
Fibroblast (WI-38) |
Reduced replicative senescence. | [174] |
| Human |
Fibrosarcoma (HT1080-p-21-9) |
Suppressed senescence induced by p21. | [175] |
| Human |
Breast Cancer (MCF-7) |
Prevented senescent morphology in nutlin-treated cells. | [175] |
| Human |
Fibroblast (HGADFN167) |
Delayed senescence caused by progerin in cells from Hutchinson-Gilford progeria patient. | [104] |
|
Mouse in vivo |
Lung | Reduced cellular senescence induced by bacterial infection. | [110] |
| Rat | Mesangial cells | Prevented senescence induced by high glucose. | [176] |
| Human | Oral epithelial keratinocytes | Protected primary cultures of cells from UV-induced cell senescence. | [177] |
| Mouse | Oral epithelial | Reduced the level of senescent epithelial cells induced by UV irradiation. | [177] |
| Mouse | Embryonic cells | Suppressed replicative senescence but blocked proliferation of cells. | [178] |
| Human |
Fibroblast (WI-38) |
Increased replicative life span. | [179] |
| Human | Endothelial cells (HPAEC) | Blocked radiation-induced senescence. | [180] |
| Human | Fibroblasts (HCA2) | Suppressed the secretion of SASPs induced by ionizing radiation. | [105] |
| Human | Fibroblasts (IMR90) | Prevented the SASP phenotype of oncogene-induced senescent cells but not growth arrest. | [106] |
| Mouse | Embryonic fibroblasts | Inhibited stress (H2O2)-induced senescence and delays replicative senescence. | [181] |
|
Mice in vivo |
Aorta | Reversed the effect of age on p19 that is associated with cellular senescence. | [111] |
| Human | Pulmonary cells (P-ECs) | Inhibited cell senescence and SASP in cells isolated from COPD patients. | [107] |
|
Zmpste24−/− mice in vivo |
Muscle stem cells | Reduced level of senescent cells in a mouse model of progeria syndrome. | [182] |
| Mouse | Lung epithelial cells (MLE-12) | Suppressed senescence and SASP in cells treated with bleomycin. | [108] |
|
Mice in vivo |
Lung | Impaired the expression of senescent markers in the lung of mice treated with bleomycin. | [108] |