Table 4.
PGT outcomes of different mosaic rate groups
| Mosaic rate group | Low (<10%) n=68 | Medium (10–50%) n=23 | High (>50%) n=9 | P value |
|---|---|---|---|---|
| Age | 36.35±5.55 | 34.61±6.14 | 30.33±4.72 | <0.05 |
| Miscarriage times | 0.5±0.73 | 0.87±0.76 | 0.56±0.73 | NS |
| Primary infertility | 38.24% (26/68) | 17.39% (4/23) | 55.55% (5/9) | NS |
| Infertile years | 5.16±4.72 | 3.00±1.69 | 4.33±2.87 | NS |
| BMI (kg/m2) | 22.7±2.91 | 22.57±1.89 | 22.28±2.48 | NS |
| 45,X mosaic rate | 0.06±0.02 | 0.20±0.13 | 0.92±0.16 | |
| AFC | 14.47±9.67 | 13.91±9.15 | 5.56±3.94 | <0.05 |
| AMH (ng/ml) | 3.29±3.48 | 3.85±3.41 | 1.26±1.29 | NS |
| Treatment protocol | ||||
| GnRH agonist | 20 | 5 | 0 | |
| GnRH antagonist | 44 | 15 | 7 | |
| Other | 4 | 3 | 2 | |
| Cancel rate | 44.1% (30/68) | 34.78% (8/23) | 55.55% (5/9) | NS |
| PGT-FISH | 29.41% (15/51) | 40% (6/15) | 60% (3/5) | NS |
| X chromosome aneuploid rate | 7.19%% (11/153) | 5.88% (3/51) | 11.11% (1/9) | NS |
| CPR/per transfer | 57.1% (28/49) | 58.3% (7/12) | 33.33% (1/3) | NS |
| Miscarriage rate | 11% (3/28) | 14.29% (1/7) | 0 | NS |
| LBR/per transfer | 50.9% (25/49) | 50% (6/12) | 33.33% (1/3) | NS |
| CLBR | 37% (25/68) | 26.09% (6/23) | 11.11% (1/9) | NS |
NS, not significantly different between each two groups; CPR, clinical pregnancy rate; MR, miscarriage rate; LBR, live birth rate