Fig. 1.

Effects of hemorrhagic shock and reperfusion that may be mitigated by SIRT1. Hemorrhagic shock in trauma results in activation of the inflammatory response, vascular endothelial dysfunction, oxidative stress, mitochondrial dysfunction, and platelet dysfunction and coagulopathy. Together, these effects contribute to organ dysfunction and multi-organ failure. SIRT1 inhibits the inflammatory response, promotes vascular endothelial function, decreases ROS, improves mitochondrial function, and can improve coagulopathy in different settings. Thus, SIRT1 has the potential to mitigate the key features of hemorrhagic shock and resuscitation that lead to organ damage and thereby improve survival