Table 2.

(A) Intraobserver agreement between modalities using a 2-tier semiquantitative consensus scores (B) Interobserver agreement between all three pathologists using a 2-tier semiquantitative scores for each modality.

	2-tier scoring system
	Kappa	Lower–Upper CI
A. Intraobserver agreement between modalities
SRH-H&E agreement	0.72	0.62–0.83
IHC-H&E agreement	0.67	0.54–0.80
IHC-SRH agreement	0.84	0.75–0.94
B. WHO grade intraobserver agreement between modalities
Low grade: IHC-SRH agreement	0.74	0.51–0.98
High grade: IHC-SRH agreement	0.65	0.5–0.8
C. Interobserver agreement between pathologists
SRH agreement	0.43	0.39–0.47
H&E agreement	0.60	0.56–0.63
IHC agreement	0.71	0.67–0.74