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. 2021 Jun 9;11:12126. doi: 10.1038/s41598-021-91655-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Chemokine receptor expression on circulating memory B cells during and early after pregnancy in MS patients and healthy controls. (A) Schematic display of chemokine receptors involved in GC-dependent organization and maturation of B cells. Expression of dark zone-associated CXCR4 and light zone-associated CXCR5, CCR6 and CXCR3 was compared between IgM⁺ (B,D) and IgG⁺ (C,E) memory B cells from first trimester (T1), third trimester (T3) and postpartum (PP) samples from 13 MS patients without a postpartum relapse (red) and 12 HC (blue). Wilcoxon signed-rank test was performed to compare the different gestational periods. Two-way ANOVA with Bonferroni’s multiple comparison test was performed to compare HC with MS patients. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.