Table 2.
Clinicopathological variables and their association with stromal hyaluronan (HA).
| HA high, n (%) | HA low, n (%) | p Value | |
|---|---|---|---|
| Gender | |||
| Male | 33 (56.9) | 20 (46.5) | 0.301 |
| Female | 25 (43.1) | 23 (53.5) | |
| T-stage | |||
| pT1 | 2 (3.4) | 1 (2.3) | 0.742 |
| pT2 | 14 (24.1) | 8 (18.6) | |
| pT3 | 42 (72.4) | 34 (79.1) | |
| pT4 | 0 | 0 | |
| N-stage | |||
| pN0 | 19 (32.8) | 11 (25.6) | 0.435 |
| pN1 | 39 (67.2) | 32 (74.4) | |
| Stage | |||
| IA | 2 (3.4) | 1 (2.3) | 0.979 |
| IB | 4 (6.9) | 3 (7.0) | |
| IIA | 12 (20.7) | 8 (18.6) | |
| IIB | 40 (69.0) | 21 (72.1) | |
| Histological grade | |||
| 1 | 16 (30.2) | 13 (30.2) | 0.994 |
| 2 | 33 (62.3) | 27 (62.8) | |
| 3 | 4 (7.5) | 3 (7.0) | |
| Perineural invasion | |||
| Positive | 35 (64.8) | 29 (67.4) | 0.786 |
| Negative | 19 (35.2) | 14 (32.6) | |
| PD-L1 in tumour cells | |||
| Positive | 1 (1.7) | 2 (4.7) | 0.392 |
| Negative | 57 (98.3) | 41 (95.3) | |
| PD-L1 in tumour stroma | |||
| Positive | 6 (10.3) | 6 (14.0) | 0.579 |
| Negative | 52 (89.7) | 37 (86.0) | |
| Immune cell score | |||
| Low | 43 (74.1) | 22 (51.2) | 0.017 |
| High | 15 (25.9) | 21 (48.8) | |
| CD73 in tumour cells | |||
| Low | 39 (67.2) | 28 (65.1) | 0.823 |
| High | 19 (32.8) | 15 (34.9) | |