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. 2021 Jun 9;12(6):598. doi: 10.1038/s41419-021-03868-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A In the nucleus, the intranuclear enzyme Drosha and DGCR8 cleave primary microRNA (pri-miRNA) to precursor microRNA (pre-miRNA). m6A modifications helps to recruit DGCR8 to target pri- miRNA and promote the formation of pre-miRNA. Meanwhile, HNRNPC can directly recognize the m6A sites. B In the cytoplasm, Dicer cleaves pre-miRNAs transported to the cytoplasm into mature miRNAs. C miRNAs regulate the expression of m6A regulatory proteins. miRNAs regulate the expression of mRNAs encoding for writers, erasers, and readers.