. 2021 May 4;43(3):1237–1251. doi: 10.1007/s11357-021-00376-4

Table 4.

Replication of the APOE protein signature

SomaID	UniProt	GeneID	NECS					LGP
SomaID	UniProt	GeneID	e₂e₂	e₂e₃	e₂e₄	e₃e₄	p	e₂e₂	e₂e₃	e₂e₄	e₃e₄	e₂e₂	p
10046-55	Q13490^*	BIRC2	5.87	3.23	3.67	0.90	1.55E−61		1.94	2.03	0.95	0.84	5.09E−134
11276-1	Q86XR8^*	CEP57	1.62	1.23	1.22	1.01	1.96E−28
7223-60	Q99584	S100A13	0.51	0.78	0.47	0.67	2.69E−23	0.18	0.53	0.16	0.46	0.16	2.26E−108
11293-14	Q6UXK5	LRRN1	0.89	0.96	1.17	1.4	1.17E−19	1.00	0.97	1.46	1.55	2.10	5.61E−105
14318-1	Q9UBQ0	VPS29	1.55	1.18	1.26	0.98	2.84E−19		1.80	1.58	0.90	0.90	3.52E−98
5918-5	Q06323^*	PSME1	1.51	1.27	1.22	0.99	5.23E−19	1.27	1.07	0.99	1.01	0.95	0.174632
2418-55	P02649^*	APOE	0.86	0.77	1.15	1.16	9.19E−11
12501-10	O75347^*	TBCA	1.08	1.02	0.88	0.83	1.60E−10	0.81	0.83	0.43	0.56	0.31	1.09E−89
12500-88	Q9UBT2^*	UBA2	1.77	1.13	1.31	0.98	5.44E−10
6378-2	Q86SI9	C5orf38	0.73	0.84	0.88	1.29	7.68E−10	0.90	0.75	0.84	1.08	1.31	1.30E−29
13732-79	Q16619	CTF1	0.94	0.95	1.2	1.11	9.63E−09
11402-17	Q8NEZ4^*	KMT2C	1.33	1.11	1.06	0.99	2.15E−08	0.73	1.06	0.75	0.94	1.14	0.035255
14643-27	O60870^*	KIN	1.23	1.08	1.22	1.02	3.10E−07
2797-56	P04114^*	APOB	0.5	0.86	0.97	1.07	3.36E−06	0.83	0.95	0.98	1.05	1.22	0.049591
9207-60	O95825	CRYZL1	0.89	0.88	0.7	1.11	7.07E−06	1.12	0.68	0.49	0.83	0.79	2.68E−23
5345-51	Q8WWK9	CKAP2	1.33	1.12	1.08	0.96	8.12E−06	0.94	1.05	0.98	0.99	1.08	0.124289

Columns e₂e₂, e₂e₃, e₂e₄, and e₃e₄ report fold change of protein level relative to e₃e₃ in the NECS and LGP. P is p-value from F test with 4 and 214 degrees of freedom, after adjusting for sex, age at blood draw, and length of sample storage. The aptamers 11276-1, 2418-55, 12500-88, 13732-79, and 14643-27 were not available in the SOMAscan array used in the LGP study