Table 1.
Molecular pathways (top ten) enriched by the common differentially expressed genes.
| Source | Pathways | Adjusted p-value | # of Genes | Related Genes |
|---|---|---|---|---|
| KEGG | Platelet activation | 1.29E-05 | 5 | ARHGEF12;ITGB3;ITGA2B;GP1BA;MYLK |
| ECM-receptor interaction | 4.83E-05 | 4 | ITGB3;ITGA2B;ITGA7;GP1BA | |
| Focal adhesion | 1.24E-04 | 5 | ITGB3;CAV1;ITGA2B;ITGA7;MYLK | |
| Regulation of actin cytoskeleton | 1.74E-04 | 5 | ARHGEF12;ITGB3;ITGA2B;ITGA7;MYLK | |
| Fluid shear stress and atherosclerosis | 3.71E-04 | 4 | ITGB3;CAV1;ITGA2B;HSP90B1 | |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 7.32E-04 | 3 | ITGB3;ITGA2B;ITGA7 | |
| Hypertrophic cardiomyopathy (HCM) | 0.001185288 | 3 | ITGB3;ITGA2B;ITGA7 | |
| Dilated cardiomyopathy (DCM) | 0.001442953 | 3 | ITGB3;ITGA2B;ITGA7 | |
| Small cell lung cancer | 0.001536035 | 3 | ITGA2B;E2F1;BCL2L1 | |
| PI3K-Akt signalling pathway | 0.001700219 | 5 | ITGB3;ITGA2B;ITGA7;HSP90B1;BCL2L1 | |
| Reactome | Hemostasis | 7.21939E-08 | 10 | SELP;EHD3;SPARC;PRKAR2B;ITGB3;CAV1;KIF4A;ITGA2B;GP1BA;CLU;PF4 |
| Platelet degranulation | 2.11035E-07 | 5 | SELP;SPARC;ITGB3;ITGA2B;CLU;PF4 | |
| Response to elevated platelet cytosolic Ca2+ | 2.78284E-07 | 5 | SELP;SPARC;ITGB3;ITGA2B;CLU;PF4 | |
| Platelet activation, signalling and aggregation | 2.60487E-06 | 6 | SELP;SPARC;ITGB3;ITGA2B;GP1BA;CLU;PF4 | |
| ECM proteoglycans | 9.89058E-06 | 4 | SPARC;ITGB3;ITGA2B;ITGA7 | |
| L1CAM interactions | 8.94941E-05 | 4 | ITGB3;KIF4A;ITGA2B;EPHB2 | |
| Platelet Aggregation (Plug Formation) | 0.000101262 | 3 | ITGB3;ITGA2B;GP1BA | |
| Cell surface interactions at the vascular wall | 0.000109012 | 4 | SELP;ITGB3;CAV1;PF4 | |
| Integrin cell surface interactions | 0.000592926 | 3 | ITGB3;ITGA2B;ITGA7 | |
| p130Cas linkage to MAPK signalling for integrin | 0.000604968 | 2 | ITGB3;ITGA2B |