Table 4.

Immunomarking for the Opioids Mu (µ), Kappa (k) and VEGF in Relation to the Presence or Absence of Recurrence in Biopsy Samples from Patients with Breast Cancer

Markers	Without recurrence	With recurrence	p-Value
µ opioid (%)
Primary tumor	3.75±3.80	1.50±1.97	0.245
Peritumoral area	1.43±2.38	0.00±0.00	0.233
Lymph node metastasis	4.77±3.73	2.60±3.44	0.286
VEGF (histoescore)
Primary tumor	8.0±3.7	8.7±3.8	0.629
Peritumoral area	3.9±3.6	6.4±4.3	0.227
Lymph node metastasis	7.9±3.7	11.3±1.5	0.095
κ opioid (histoescore)
Primary tumor	11.1±1.8	10.5±2.5	0.653
Peritumoral area	10.8±2.8	12.0±0.1	0.574
Lymph node metastasis	10.8±2.2	7.2±3.7	0.033*

Mann-Whitney test; p<0.05 (mean ±SD)