Table 6.
Correlation between Opioid Receptors and VEGF, ki-67 and TUNEL in Luminal A and Luminal B Breast Cancer
| µ opioid | VEGF | k opioid | Ki-67 | TUNEL | |
|---|---|---|---|---|---|
| Tumor | |||||
| µ opioid | - | p=0.115 (r=0.256) | *p=0.011 (r=0.408) | p=0.126 (r=-0.253) | *p=0.028 (r=0.361) |
| VEGF | - | - | p=0.211 (r=0.205) | *p=0.018 (r=-0.378) | p=0.627 (r=0.081) |
| k opioid | - | - | - | p=0.576 (r=-0.094) | p=0.965 (r=-0.008) |
| Ki-67 | - | - | - | - | p=0.843 (r=-0.034) |
| TUNEL | - | - | - | - | - |
| Control | |||||
| µ opioid | - | *p=0.044 (r=-0.509) | p=0.555 (r=0.173) | p=0.374 (r=0.447) | p=0.579 (r=0.136) |
| VEGF | - | - | p=0.895 (r=-0.035) | p=0.237 (r=-0.514) | p=0.207 (r=0.280) |
| k opioid | - | - | - | p=1.000. (r=0.212.) | p=0.649 (r=0.119) |
| Ki-67 | - | - | - | - | p=1.000 (r=0.343) |
| TUNEL | - | - | - | - | - |
| Lymph node metastasis | |||||
| µ opioid | - | p=0.406 (r=0.167) | *p=0.002 (r=0.568) | *p=0.047 (r=-0.400) | p=0.570 (r=-0.117) |
| VEGF | - | - | p=0.387 (r=0.170) | p=0.729 (r=0.071) | *p=0.047 (r=0.374) |
| k opioid | - | - | - | p=0.787 (r=-0.056) | p=0.228 (r=0.240) |
| Ki-67 | - | - | - | - | p=0.575 (r=0.120) |
| TUNEL | - | - | - | - | - |
*p<0.05, Spearamn’s correlation. In tumor, k opioid was directly correlated with µ opioid (p = 0.001) and TUNEL (p = 0.028), however ki67 was inversely correlated with VEGF (p = 0.018). In control tissue µ opioid and VEGF were directly correlated (p = 0.044) and in Lymph node metastasis k opioid was directly correlated with µ opioid (p = 0.001) and inversely correlated with ki-67. Additionaly, in lymph node metastasis TUNEL and VEGF were directly correlated (p = 0.047).