Table 1.
Top 15 KEGG Pathways for Differentially Expressed Genes
| No. | Pathway ID | KEGG Term | No. of Genes | Corrected ‘p’ Value |
|---|---|---|---|---|
| OC tissues vs. Healthy normal tissues | ||||
| 1 | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 10 | 6.52E-06 |
| 2 | hsa04657 | IL-17 signaling pathway | 10 | 7.17E-06 |
| 3 | hsa04512 | ECM-receptor interaction | 8 | 0.000192 |
| 4 | hsa04060 | Cytokine-cytokine receptor interaction | 13 | 0.000358 |
| 5 | hsa05146 | Amoebiasis | 8 | 0.000436 |
| 6 | hsa04062 | Chemokine signaling pathway | 10 | 0.000735 |
| 7 | hsa00350 | Tyrosine metabolism | 5 | 0.000773 |
| 8 | hsa04668 | TNF signaling pathway | 7 | 0.003381 |
| 9 | hsa05204 | Chemical carcinogenesis | 6 | 0.003796 |
| 10 | hsa05222 | Small cell lung cancer | 6 | 0.006394 |
| 11 | hsa04620 | Toll-like receptor signaling pathway | 6 | 0.008784 |
| 12 | hsa05165 | Human papillomavirus infection | 11 | 0.008829 |
| 13 | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 6 | 0.009084 |
| 14 | hsa05202 | Transcriptional misregulation in cancer | 8 | 0.009088 |
| 15 | hsa05219 | Bladder cancer | 4 | 0.009202 |
| OC tissues vs. Adjacent normal tissues | ||||
| 1 | hsa04512 | ECM-receptor interaction | 12 | 2.04E-07 |
| 2 | hsa04974 | Protein digestion and absorption | 12 | 2.51E-07 |
| 3 | hsa04657 | IL-17 signaling pathway | 11 | 1.82E-06 |
| 4 | hsa04510 | Focal adhesion | 14 | 1.12E-05 |
| 5 | hsa05146 | Amoebiasis | 10 | 2.60E-05 |
| 6 | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 9 | 0.000141 |
| 7 | hsa05165 | Human papillomavirus infection | 16 | 0.000146 |
| 8 | hsa04151 | PI3K-Akt signaling pathway | 15 | 0.001095 |
| 9 | hsa04926 | Relaxin signaling pathway | 8 | 0.005343 |
| 10 | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 7 | 0.005663 |
| 11 | hsa04610 | Complement and coagulation cascades | 6 | 0.013473 |
| 12 | hsa05323 | Rheumatoid arthritis | 6 | 0.016973 |
| 13 | hsa05222 | Small cell lung cancer | 6 | 0.017279 |
| 14 | hsa00350 | Tyrosine metabolism | 4 | 0.017942 |
| 15 | hsa05219 | Bladder cancer | 4 | 0.023482 |
| Adjacent normal tissues vs. Healthy normal tissues† | ||||
| 1 | hsa05132 | Salmonella infection | 9 | 0.0031677 |
| 2 | hsa05100 | Bacterial invasion of epithelial cells | 5 | 0.00546264 |
| 3 | hsa04520 | Adherens junction | 5 | 0.00598445 |
| 4 | hsa04670 | Leukocyte transendothelial migration | 6 | 0.00773211 |
| 5 | hsa04390 | Hippo signaling pathway | 7 | 0.0100045 |
| 6 | hsa04145 | Phagosome | 6 | 0.0171834 |
| 7 | hsa04015 | Rap1 signaling pathway | 7 | 0.0196547 |
| 8 | hsa00010 | Glycolysis / Gluconeogenesis | 4 | 0.0251694 |
| 9 | hsa04530 | Tight junction | 6 | 0.0261049 |
| 10 | hsa05135 | Yersinia infection | 5 | 0.0267642 |
| 11 | hsa05418 | Fluid shear stress and atherosclerosis | 5 | 0.0391383 |
| 12 | hsa05203 | Viral carcinogenesis | 6 | 0.041833 |
| 13 | hsa04510 | Focal adhesion | 6 | 0.0434251 |
| 14 | hsa04810 | Regulation of actin cytoskeleton | 6 | 0.0477088 |
†Only 14 terms were significantly enriched for KEGG pathway. Abbreviations: KEGG, kyoto encyclopedia of genes and genomes; OC, oral cancer.