Table 3.

Genetic Association of FAS-670 A>G and FASL -844 T>C Polymorphisms with IM Response in CML Patient

FAS -670 A>G	Treatment status (n=93)
	Resistance (n=46)	Response (n=47)	P value	Adjusted OR (95% CI)	P value
Genotype
AA	8 (17.4%)	5 (10.6%)	0.348	1 (Reference)
AG	22 (47.8%)	32 (68.1%)	0.048*	0.429 (0.124-1.488)	0.43
GG	16 (34.8%)	10 (21.3%)	0.147	1.000 (0.255-3.929)	1
Allele
A	38 (41.3%)	42 (44.7%)		1 (Reference)
G	54 (58.7%)	52 (55.3%)	0.639	1.148 (0.642-2.052)	0.639
FASL-844 T>C	Treatment status (n=90)
	Resistance (n=45)	Response (n=45)	P value	Adjusted OR (95% CI)	P value
Genotype
TT	17 (37.8%)	5 (11.1%)	0.003*	1 (Reference)	-
TC	7 (15.5%)	16 (35.6%)	0.029*	0.129 (0.034-0.489)	0.003*
CC	21 (46.7%)	24 (53.3%)	0.527	0.257 (0.081-0.818)	0.021*
Allele
T	41 (45.6%)	26 (28.9%)		1 (Reference)
C	49 (54.4%)	64 (71.1%)	0.002*	0.486 (0.262-0.899)	0.021*

*p<0.05 statistically significant; OR, odd ratio; CI, confidence interval